Can we switch COVID-19 vaccine shots with pills? Looks like the time is not far as researchers in Japan claim they have developed new methods to administer fast-acting COVID-19 vaccines orally.
According to the study, published in the journal Biology Methods and Protocol, scientists from Japan’s Intelligence and Technology Lab tested a vaccine pill on monkeys to find their effectiveness. The pills showed substantial effectiveness in producing antibodies against COVID-19 without any visible side effects.
The pill, designed for under-the-tongue administration, is very much like the vaccine shot, as it contains a non-active portion of the virus. However, unlike the vaccine, the pill releases the inactivated virus into the mucus and helps to elicit a faster response in tackling the actual virus before it infects the body.
“The best way to neutralize viruses is before they can enter inside human cells but are only on the external surface of epithelial cells that line and produce mucus in the lungs, nose and mouth. A specific class of antibodies, known as Immunoglobulin A, operates in mucus and can disable viruses. However, production of specific immunoglobulins/antibodies for a given virus has to be first induced by vaccination,” researchers said in a news release.
Since the coronavirus primarily affects bronchial cells just like a flu virus, researchers aimed to trigger the production of virus antigen-specific Immunoglobulin A in the mucosal lining rather than in the bloodstream.
Scientists had earlier developed nasal or oral vaccines, and they were found to be more effective in inducing Immunoglobulins A than the subcutaneous vaccines. However, these vaccines had side effects such as headaches and fever and impacted on the central nervous system or lungs.
Researchers hope after further research and clinical trials, the new drug can be used as an effective preventive strategy against the coronavirus.
The U.S. Food and Drug Administration (FDA) and the Centers for Disease…
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